Trample
{5}: Permanents you control gain indestructible until end of turn.
{5}, Exile Soul of New Phyrexia from your graveyard: Permanents you control gain indestructible until end of turn.
Exiling the Soul from your graveyard is part of the last ability's activation cost. A player can't remove the Soul in response to prevent you from activating the ability.
You can activate the last ability only if the Soul is in your graveyard.