Target creature gets +3/+3 until end of turn and must be blocked this turn if able.
If each creature the defending player controls can't block for any reason (such as being tapped), then the affected creature isn't blocked. If there's a cost associated with blocking the affected creature, the defending player isn't forced to pay that cost, so it doesn't have to be blocked in that case either.
Only one creature is required to block the affected creature. Other creatures may also block it and are free to block other creatures or not block at all.