All Sliver creatures have poisonous 1. (Whenever a Sliver deals combat damage to a player, that player gets a poison counter. A player with ten or more poison counters loses the game.)
A player with ten or more poison counters loses the game as a state-based action, even if no permanents with poisonous are on the battlefield.
If a creature has multiple instances of poisonous, each triggers separately.
Poisonous 1 causes the player to get just one poison counter when a Sliver deals combat damage to them, no matter how much damage that Sliver dealt.
If the creature type of a Sliver changes so it’s no longer a Sliver, it will no longer be affected by its own ability. Its ability will continue to affect other Sliver creatures.